If you are looking for the gallery, see Colt Python Gallery.
Deputy Rick Grimes (Andrew Lincoln) carries a six-inch barreled Colt Python .357 Magnum revolver as his duty sidearm in the series. He so far has used it the most in the pilot episode but has carried it through every episode so far and has fired it at least twice since, once in the attack in Season 1 Episode 4, Vatosas well as drawn it multiple times. He also briefly wields it in Season 1 Episode 5, Wildfire. Rick once again fires it as the group flee the CDC in Season 1 Episode 6, TS-19. Of note is that when Grimes fires the gun in a very tight, enclosed space (in this case, inside a tank), it actually severely disorients him and hurts his hearing, unlike most movies or shows that have people firing guns indoors or in other enclosed spaces without being fazed. In Season 2 Episode 2, Bloodletting, Rick hands his Python off to Otis (Pruitt Taylor Vince) to take on a dangerous mission with Shane for medical supplies for Carl. Otis fires it in the following episode Season 2 Episode 3, Save the Last One at a herd of zombies as they attempt escape from an un-named school. Rick draws it again in Season 2 Episode 5, Chupacabra at a supposed Walker. Season 2 Episode 7, Pretty Much Dead Already, we finally see Rick fire his Python once for the first time in Season 2. This time to put down an infected group member called Sophia Peletier. He then uses it to shoot and kill two threatening survivors called Dave and Tony at the bar in the premiere of season 2's second half. Following an unfortunate accident in Season 2 Episode 11, Judge, Jury, Executioner; Daryl Dixon (Norman Reedus) uses Rick's revolver to put down a mortally wounded member of the group when Rick can't. Rick then fires it to save Hershel's life in the season finale as a walker creeps up behind him.